Nope, I am not suggesting that you blindfold yourself and take to the driver's seat, although you might do better than the cell phone addicts on the road.
I'm talking about the ultimate adventure. Pack an overnight bag. Get in the car. Pick a direction. Drive. Wander. Have lunch in a strange town you never would have stopped in before. Pick the diner it looks like the locals use. Don't you dare use a chain restaurant! You can tell by the FoodTV show, "Drive-ins, Diners and Dives" that the best food is had at diners! This is all about poking around the unknown. See sights. Wander. Get out and walk around. Take a road that looks interesting. Keep going and then, when you feel the urge, stop and rent a hotel room. No reservations. In a town you either never went to or never thought to stop and sleepover in. Ask someone at the hotel desk if there's a museum in town or a tourist attraction. Do it the next day.
Simple and completely unique way to spend your weekend. Have fun! Report back!